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KMID : 0379119870150020123
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Korean Journal of Mycology
1987 Volume.15 No. 2 p.123 ~ p.123
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Characterization of Methionine Analogue Resistant Mutant Cephalosporium acremonium MAR-80
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Lee, Jung Joon
Mheen, Tae Ick/Choi, Sang Ho/Lee, Kyoung
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Abstract
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Cephalosporium acremonium MAR-80, a strain of methionine analogue resistant mutant, showed good activity of sulfate utilization as only sulfur source. The effect of methionine on the sulfate uptake system was investigated by using Na₂^(35) SO₄ as a tracer in the resting cell system. And then, it was revealed that sulfate permease of this strain was less repressed and/or less inhibited by methionine than parent type. This deregulation was due to low activity of methionine uptake, which was operated by diffusion to a certain extent. From these studies, it could be anticipated that the improved productivity of Cephalosporin C and lower dependent of Cephalosporin C production on methionine were related to the increased uptake rate of sulfate.
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